| Titre : | Diagnosis and treatment of cervical intraepithelial neoplasia grade 3 : a registry-based study in the Romagna region of Italy (1986-1993). (1999) |
| Auteurs : | M. SERAFINI ; L. BUCCHI ; C. CORDARO ; F. FALCINI ; E. MONTANARI ; Romagna Cancer Registry. Luigi Pierantoni Hospital. Forl. ITA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 28, n° 2, 1999) |
| Pagination : | 196-203 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Diagnostic ; Thérapeutique ; Chirurgie ; Homme ; Femme ; Registre ; Epidémiologie ; Italie ; Europe |
| Résumé : | [BDSP. Notice produite par INIST YEAR0xKf. Diffusion soumise à autorisation]. Background Treatment of cervical intraepithelial neoplasia grade 3 (CIN3) is one of the most unexplored issues of the monitoring of cervical cancer screening. We evaluated (1) the frequency of major patterns of diagnosis and treatment of CIN3 (ICD-O code 8070.2), (2) the determinants of hysterectomy as a first choice treatment, and (3) the determinants of invasive cervical squamous carcinoma (CSC) detection among CIN3 cases treated by hysterectomy. Methods A population-based, retrospective, descriptive (objective 1) and analytical (objectives 2 and 3) study was conducted by the Romagna Cancer Registry (Northern Italy). Included were 316 CIN3 patients (median age, 38.5 years ; range, 21-80) registered between 1986 and 1993 and meeting one of the following eligibility criteria : histological diagnosis of CIN3 on biopsy with any subsequent treatment, histological diagnosis of CIN3 on conization, histological diagnosis of CIN3 on hysterectomy with previous negative/benign (<=CIN2) biopsy or conization. Multivariate associations were evaluated by the multiple logistic regression. Results Of 316 patients, 264 (84%) were first diagnosed on biopsy, 39 (12%) on conization, and 13 (4%) on hysterectomy. Among the 264 patients diagnosed on biopsy, the first choice treatment was local destructive therapy for 16 (6%), conization for 155 (59%) and hysterectomy for 93 (35%). (...) |
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