| Titre : | A community outbreak of Legionnaires'disease linked to hospital cooling towers : an epidemiological method to calculate dose of exposure. (1999) |
| Auteurs : | C.M. BROWN ; R.F. BREIMAN ; M. CETRON ; B.S. FIELDS ; A.L. HATHCOCK ; J. HOFMANN ; H.B. LIPMAN ; G.C. LLEWELLYN ; P.J. NUORTI ; Centers for Disease Control and Prevention. National Center for Infectious Diseases. Division of Bacterial and Mycotic Diseases. USA ; Delaware Health and Social Services. Division of Public Health. Epidemiology Section. USA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 28, n° 2, 1999) |
| Pagination : | 353-359 |
| Langues: | Anglais |
| Mots-clés : | Maladie légionnaire ; Bactériose ; Infection ; Hospitalisation ; Exposition ; Contamination ; Epidémiologie ; Facteur risque ; Homme ; Etats Unis ; Amérique ; Appareil respiratoire [pathologie] ; Pneumonie ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST 6R0xd1Zf. Diffusion soumise à autorisation]. Background From July to September 1994,29 cases of community-acquired Legionnaires'disease (LD) were reported in Delaware. The authors conducted an investigation to a) identify the source of the outbreak and risk factors for developing Legionella pneumophila serogroup 1 (Lp-1) pneumonia and b) evaluate the risk associated with the components of cumulative exposure to the source (i.e. distance from the source, frequency of exposure, and duration of exposure). Methods A case-control study matched 21 patients to three controls per case by known risk factors for acquiring LD. Controls were selected from patients who attended the same clinic as the respective case-patients. Water samples taken at the hospital, from eight nearby cooling towers, and from four of the patient's homes were cultured for Legionella. Isolates were subtyped using monoclonal antibody (Mab) analysis and arbitrarily primed polymerase chain reaction (AP-PCR). Results Eleven (52%) of 21 case-patients worked at or visited the hospital compared with 17 (27%) of 63 controls (OR 5.0,95% CI : 1.1-29). For those who lived, worked, or visited within 4 square miles of the hospital, the risk of illness decreased by 20% for each 0.10 mile from the hospital ; it increased by 80% for each visit to the hospital ; and it increased by 8% for each hour spent within 0.125 miles of the hospital. Lp-1 was isolated from three patients and both hospital cooling towers. (...) |
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