| Titre : | The effect of human immunodeficiency virus-1 infection and stunting on measles immunoglobulin-G levels in children vaccinated against measles in Uganda. (1999) |
| Auteurs : | P. WAIBALE ; S.J. BOWLIN ; Eajr MORTIMER ; C. WHALEN ; Department of Epidemiology and Biostatistics. School of Medicine. Case Western Reserve University. Cleveland. OH. USA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 28, n° 2, 1999) |
| Pagination : | 341-346 |
| Langues: | Anglais |
| Mots-clés : | Sida ; Virose ; Infection ; VIH ; Rétrovirus ; Virus ; Rougeole ; Vaccination ; Concentration ; Plasma sanguin ; Epidémiologie ; Evaluation ; Efficacité ; Enfant ; Homme ; Prévention santé ; Ouganda ; Afrique ; Immunopathologie |
| Résumé : | [BDSP. Notice produite par INIST JfFfmR0x. Diffusion soumise à autorisation]. Background Measles is an important public health problem in developing nations and there is concern that immune response to measles vaccination may be compromised by paediatric human immunodeficiency virus (HIV) infection. Therefore, this study investigated the relationship of immunoglobulin-G (Ig-G) antibody levels in children vaccinated against measles and HIV-1 infection. Further analysis was done to assess the influence of nutritional status on this relationship Methods The authors measured HIV and measles antibodies in 243 vaccinated children aged 17-41 months from Kampala, Uganda. Children were from paediatric and HIV clinics. Potential confounders of this relationship included nutritional anthropometric measures, age at and time since vaccination, measles exposure, family crowding, vaccination clinic and gender. Univariable and multivariable analyses were used to study these associations. Results Fifty children (21%) were HIV infected. In univariable analysis, low measles antibody (<15 ELISA units/ml) was associated with HIV (P=0.05 ; odds ratio (OR)=1.86) and stunting (P=0.06 ; OR=1.68). Stunting, measured as height-for-age and defined as<-2 standard deviations of the reference population median, was a surrogate for chronic malnutrition. HIV was strongly associated with stunting (P=0.0001 ; OR=6.62). In multiple logistic regression, HIV was not associated with low measles antibodies ; however, stunting (P=0.04 ; OR=1.81), and<3 children in the home (P=0. (...) |
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