| Titre : | Proceedings of Health Conference'97 - Great Lakes/St. Lawrence. Motor function in aging Great Lakes fisheaters. (1999) |
| Auteurs : | S.L. SCHANTZ ; Christopher-T DE ROSA, éd. ; J.C. GARDINER ; D.M. GASIOR ; Andrew-P GILMAN, éd. ; H.E.B. HUMPHREY ; R.J. MCCAFFREY ; Zemoria-A ROSEMOND, éd. ; A.M. SWEENEY ; Agency for Toxic Substances and Disease Registry. Us Department of Health and Human Services. Atlanta. GA. USA ; Department of Epidemiology. College of Human Medicine. Michigan State University. East Lansing. MI. USA ; Health Canada. CAN ; Health Conference'97 - Great Lakes/St. Lawrence. (12/05/1997; Montréal. PQ. CAN) |
| Type de document : | Article |
| Dans : | Environmental research (vol. 80, n° 2, 1999) |
| Pagination : | S46-S56 |
| Langues: | Anglais |
| Mots-clés : | PCB ; Etude comparée ; Taux ; Sang ; Vieillissement ; Trouble motricité ; Personne âgée ; Homme ; Sexe ; Age ; Poisson ; Aliment ; Consommation alimentaire ; Habitude alimentaire ; Pollution eau ; Système nerveux [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST E7R0x686. Diffusion soumise à autorisation]. Exposure to contaminants in Great Lakes fish has been linked to impaired neuropsychological functioning in children, but neurological function of exposed adults has not been evaluated. This report describes a cross-sectional analysis of the effects of PCB/DDE exposure from contaminated fish on fine motor function in older adults. The subjects were 50-90-year-old Michigan residents who were members of a previously established study cohort. Fisheaters ate 24 lbs or more of sport-caught Lake Michigan fish/year at the time they were originally recruited in 1980-1982. Age-and sex-matched non-fisheaters ate 6 or fewer lbs/year. Outcome measures were scores on the Static Motor Steadiness Test (SMST) and Grooved Pegboard Test (GPT). PCB/DDE exposure was determined through serum analyses performed at the time of recruitment into the present study in 1993-1995. Because of the high correlation between serum PCB and DDE levels in this sample (Spearman r=0.64, P<0.0001), the effects of the two contaminants were assessed jointly using a single derived exposure variable : Low=both PCB and DDE at or below the medians of their respective distributions, intermediate=PCB and/or DDE in the third quartile, and high=PCB and/or DDE in the upper quartile. In unadjusted analyses, high exposure to PCBs/DDE was associated with significantly poorer performance on the GPT (P=0.03). (...) |
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