| Titre : | Inverse graded relation between alcohol consumption and active infection with Helicobacter pylor. (1999) |
| Auteurs : | H. BRENNER ; G. ADLER ; G. BODE ; D. ROTHENBACHER ; Department of Epidemiology. University of Ulm. Ulm. DEU ; Department of Internal Medicine I. University of Ulm. Ulm. DEU |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 149, n° 6, 1999) |
| Pagination : | 571-576 |
| Langues: | Anglais |
| Mots-clés : | Bactériose ; Infection ; Bactérie ; Homme ; Allemagne ; Europe ; Epidémiologie ; Prévalence ; Consommation alimentaire ; Boisson alcoolisée ; Vin ; Bière ; Appareil digestif [pathologie] ; Estomac [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST 8nR0xzHt. Diffusion soumise à autorisation]. Alcoholic beverages are known to have strong antibacterial activity. It is unclear, however, to what degree their consumption affects colonization of the human stomach with the bacterium Helicobacter pylori, a risk factor of various chronic diseases. The authors assessed the relation between alcohol consumption and active infection with H. pylori in a cross-sectional study among employees of a health insurance company and their household members (n=425) in southern Germany. Quantitative information on alcohol consumption by beverage type and other factors that were known or suspected to be related to infection status was collected by a standardized questionnaire, and active infection was measured by the 13C-urea breath test. After control for confounding factors, there was a monotonic inverse graded relation between alcohol consumption and H. pylori infection (p for trend=0.017). The odds ratio of infection among subjects who consumed more than 75 g of alcohol per week compared with subjects who did not drink alcohol was 0.31 (95 percent confidence interval 0.12-0.81). The inverse relation with H. pylori infection was stronger for alcohol consumed in the form of wine than for alcohol from beer. Notwithstanding its cross-sectional design, this study seems to support the hypothesis that alcohol consumption, particularly wine consumption, may reduce the odds of active infection with H. pylori. |
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