| Titre : | Prospective cohort Study of antioxidant vitamin supplement use and the risk of age-related maculopathy. (1999) |
| Auteurs : | W.G. CHRISTEN ; U.A. AJANI ; J.E. BURING ; E.C. CHEW ; R.J. GLYNN ; C.H. HENNEKENS ; J.E. MANSON ; D.A. SCHAUMBERG ; Department of Ambulatory Care and Prevention. Brigham and Women's Hospital and Harvard Medical School. Boston. MA. USA ; Department of Epidemiology. Harvard School of Public Health. Boston. MA. USA ; Department of Medicine. Division of Preventive Medicine. Brigham and Women's Hospital and Harvard Medical School. Boston. MA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 149, n° 5, 1999) |
| Pagination : | 476-484 |
| Langues: | Anglais |
| Mots-clés : | Homme ; Prévention santé ; Evaluation ; Incidence ; Prévention thérapeutique ; Vitamine E ; Supplémentation ; Antioxydant ; Questionnaire ; Etats Unis ; Amérique ; Oeil [pathologie] ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST kINR0xKU. Diffusion soumise à autorisation]. In a prospective cohort study, the authors examined whether self-selection for antioxidant vitamin supplement use affects the incidence of age-related maculopathy. The study population consisted of 21,120 US male physician participants in the Physicians'Health Study I who did not have a diagnosis of age-related maculopathy at baseline (1982). During an average of 12.5 person-years of follow-up, a total of 279 incident cases of age-related maculopathy with vision loss to 20/30 or worse were confirmed by medical record review. In multivariate analysis, as compared with nonusers of supplements, persons who used vitamin E supplements had a possible but nonsignificant 13% reduced risk of age-related maculopathy (relative risk=0.87,95 percent confidence interval (Cl) 0.53-1.43), while users of multivitamins had a possible but nonsignificant 10% reduced risk (relative risk=0.90,95% Cl 0.68-1.19). Users of vitamin C supplements had a relative risk of 1.03 (95% Cl 0.71-1.50). These observational data suggest that among persons who self-select for supplemental use of antioxidant vitamin C or E or multivitamins, large reductions in the risk of age-related maculopathy are unlikely. Randomized trial data are accumulating to enable reliable detection of the existence of more plausible small-to-moderate benefits of these agents alone and in combination on age-related maculopathy. |
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