| Titre : | Lead and hypertension in a sample of middle-aged women. (1999) |
| Auteurs : | S.A. KORRICK ; H. HU ; D.J. HUNTER ; A. ROTNITZKY ; F.E. SPEIZER ; Channing Laboratory. Department of Medicine. Brigham and Women's Hospital. Harvard Medical School. Boston. USA |
| Type de document : | Article |
| Dans : | American journal of public health (vol. 89, n° 3, 1999) |
| Pagination : | 330-335 |
| Langues: | Anglais |
| Mots-clés : | Homme ; Femme ; Plomb ; Hypertension artérielle ; Facteur risque ; Os ; Sang ; Concentration ; Epidémiologie ; Etats Unis ; Amérique ; Appareil circulatoire [pathologie] ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST R0xDVyAp. Diffusion soumise à autorisation]. Objectives. The role of lead exposure a risk factor for hypertension is less well defined among women than among men. This case-control study assessed the relation of blood and bone lead concentrations to hypertension in women. Methods. Cases and controls were a subsample of women from the Nurses'Health Study. Hypertension was defined as a physician diagnosis of hypertension between 1988 and 1994 or measure systolic blood pressure >=140 mm Hg or diastolic blood pressure >= 90 mm Hg. Results. Mean (SD) blood lead concentration was 0.15 (0.11) mumol/L ; mean tibia and patella lead concentratikons by K-x-ray fluorescence were 13.3 (9.0) and 17.3 (11.1) mug/g, respectively. After adjustment for potentially confounding factors, an increase from the 10th and the 90th percentile of patella lead values (25 mug/g) was associated with approximately 2-fold (95% confidence interval=1.1,3.2=increased risk of hypertension. There was no association between hypertension and either blood or tibia lead concentrations. Conclusions. These findings support a potentially important role for low-level lead exposure as a risk factor for hypertension among non-occupationally exposed women. |
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