| Titre : | Cardiovascular disease in insulin dependent diabetes mellitus : similar rates but different risk factors in the US compared with Europe. (1998) |
| Auteurs : | T.J. ORCHARD ; K.Z. FORREST ; J.H. FULLER ; L.K. STEVENS ; Department of Epidemiology and Public Health. University College London. London. GBR ; Department of Epidemiology. Graduate School of Public Health. University of Pittsburgh. Pittsburgh. PA. USA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 27, n° 6, 1998) |
| Pagination : | 976-983 |
| Langues: | Anglais |
| Mots-clés : | Diabète insulinodépendant ; Appareil circulatoire [pathologie] ; Epidémiologie ; Facteur risque ; Prévalence ; Homme ; Etats Unis ; Amérique ; Glucose ; Europe ; Glande endocrine [pathologie] ; Immunopathologie ; Maladie autoimmune ; Etude comparée ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST bg1IR0xB. Diffusion soumise à autorisation]. Background Cardiovascular disease (CVD) in insulin dependent diabetes mellitus (IDDM) has been linked to renal disease. However, little is known concerning international variation in the correlations with hyperglycaemia and standard CVD risk factors. Methods A cross-sectional comparison was made of prevalence rates and risk factor associations in two large studies of IDDM subjects : the Pittsburgh Epidemiology of Diabetes Complications Study (EDC) and the EURODIAB IDDM Complications Study from 31 centres in Europe. Subgroups of each were chosen to be comparable by age and duration of diabetes. The EDC population comprises 286 men (mean duration 20. years) and 281 women (mean duration 19.9 years) ; EURODIAB 608 men (mean duration 18.1 years) and 607 women (mean duration 18.9 years). The mean age of both populations was 28 years. Cardiovascular disease was defined by a past medical history of myocardial infarction, angina, and/or the Minnesota ECG codes (1.1-1.3,4.1-4.3,5.1-5.3,7.1). Results Overall prevalence of CVD was similar in the two populations (i.e. men 8.6% versus 8.0%, women 7.4% versus 8.5%, EURODIAB versus EDC respectively), although EDC women had a higher prevalence of angina (3.9% versus 0.5%, P<0.001). Multivariate modelling suggests that glycaemic control (HbA1c) is not related to CVD in men. Age and high density lipoprotein cholesterol predict CVD in EURODIAB, while triglycerides and hypertension predict CVD in EDC. (...) |
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