| Titre : | Precancerous lesions in two counties of China with contrasting gastric cancer risk. (1998) |
| Auteurs : | W.C. YOU ; W.J. BLOT ; J.C. BRAVO ; Y.S. CHANG ; P. CORREA ; Jfjr FRAUMENI ; M.H. GAIL ; Y.R. HU ; J.Y. LI ; H.Q. LI ; LIAN ZHANG . (.) ; W.D. LIU ; J.L. MA ; G.W. XU ; C.L. ZHAO ; Beijing Institute for Cancer Research and School of Oncology. Beijing Medical University. Beijing. CHN ; Louisiana State University Medical Center. New Orleans. LA. USA ; National Cancer Institute. Bethesda. MD. USA ; Weifang Blood Center. Weifang Shandong. CHN |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 27, n° 6, 1998) |
| Pagination : | 945-948 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Estomac ; Endoscopie ; Epidémiologie ; Facteur risque ; Homme ; Chine ; Asie ; Etude comparée ; Appareil digestif [pathologie] ; Estomac [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST iCsWR0x2. Diffusion soumise à autorisation]. Background Gastric cancer (GC) is one of the most common cancers worldwide and shows remarkable geographical variation even within countries such as China. Linqu County in Shandong Province of northeast China has a GC rate that is 15 times higher than that of Cangshan County in Shandong, even though these counties are within 200 miles of each other. Method In order to evaluate the frequency of precancerous gastric lesions in Linqu and Cangshan Counties we examined 3400 adults in Linqu County and 224 adults in Cangshan County. An endoscopic examination with four biopsies was performed in each individual of the two populations. Results The prevalence of intestinal metaplasia (IM) and dysplasia (DYS) was 30% and 15.1%, respectively, in Linqu compared to 7.9% and 5.6% in Cangshan (P<0.01). Within these histological categories, advanced grades were found more often in Linqu than in Cangshan. The prevalences of IM and DYS were more common at each biopsy site in Linqu, where the lesions also tended to affect multiple sites. Conclusions The findings of this study support the concept that IM and DYS are closely correlated with risks of GC and represent late stages in the multistep process of gastric carcinogenesis. |
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