| Titre : | Helicobacter pylor, infection, garlic intake and precancerous lesions in a Chinese population at low risk of gastric cancer. (1998) |
| Auteurs : | W.C. YOU ; W.J. BLOT ; J.C. BRAVO ; Y.S. CHANG ; P. CORREA ; Jfjr FRAUMENI ; M.H. GAIL ; Y.R. HU ; J.Y. LI ; H.Q. LI ; LIAN ZHANG . (.) ; W.D. LIU ; J.L. MA ; G.W. XU ; C.L. ZHAO ; Beijing Institute for Cancer Research and School of Oncology. Beijing Medical University. Beijing. CHN ; Louisiana State University Medical Center. New Orleans. LA. USA ; National Cancer Institute. Bethesda. MD. USA ; Weifang Blood Center. Weifang Shandong. CHN |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 27, n° 6, 1998) |
| Pagination : | 941-944 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Estomac ; Bactérie ; Infection ; Examen sérologique ; Régime alimentaire ; Epidémiologie ; Facteur risque ; Protection ; Homme ; Chine ; Asie ; Prévention santé ; Appareil digestif [pathologie] ; Estomac [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST oz4mR0xr. Diffusion soumise à autorisation]. Background Cangshan County of Shandong Province has one of the lowest rates of gastric cancer (GC) in China. While intestinal metaplasia (IM) and dysplasia (DYS) are less common in Cangshan than in areas of Shandong at high risk of GC, these precursor lesions nevertheless affect about 20% of adults age >=55. Subjects In order to evaluate determinants of IM and DYS in Cangshan County, a low risk and Setting area of GC a survey was conducted among 214 adults who participated in a gastroscopic screening survey in Cangshan County in 1994. Method A dietary interview and measurement of serum Helicobacter pylori antibodies were performed. Results The prevalence of H. pylori was lowest (19%) among those with normal gastric mucosa, rising steadily to 35% for superficial gastritis (SG), 56% for chronic atrophic gastritis (CAG), 80% for IM, and 100% for DYS. The prevalence odds of precancerous lesions were compared with the odds of normal histology or SG. The odds ratio (OR) or CAG associated with H. pylori positivity was 4.2 (95% confidence interval [CI] : 1.7-10.0), while the OR of IM/DYS associated with H. pylori positivity was 31.5 (95% Cl : 5.2-187). After adjusting for H. pylori infection, drinking alcohol was a risk factor for CAG (OR=3.2,95% CI : 1.1-9.2) and IM/DYS (OR=7.8,95% CI : 1.3-47.7). On the other hand, consumption of garlic showed non-significant protective effects and an inverse association with H. pylori infection. (...) |
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