| Titre : | Constitutional, biochemical and lifestyle correlates of fibrinogen and factor VII activity in polish urban and rural populations. (1998) |
| Auteurs : | A. PAJAK ; G. BRODA ; C.E. DAVIS ; E. KAWALEC ; T.A. MANOLIO ; J. PIKON ; A. PYTLAK ; S. RYWIK ; R.P. Thomas ; Department of Cvd Epidemiology and Prevention. Stefan Cardinal Wyszynski National Institute of Cardiology. Warsaw. POL ; School of Public Health. University of North Carolina at Chapel Hill. NC. USA ; Unit of Clinical Epidemiology and Population Studies. School of Public Health. Collegium Medicum. Jagiellonian University. Krakow. POL |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 27, n° 6, 1998) |
| Pagination : | 953-961 |
| Langues: | Anglais |
| Mots-clés : | Cardiopathie coronaire ; Artériosclérose ; Taux ; Plasma sanguin ; Condition vie ; Epidémiologie ; Facteur risque ; Homme ; Etude comparée ; Appareil circulatoire [pathologie] ; Vaisseau sanguin [pathologie] ; Pologne ; Europe |
| Résumé : | [BDSP. Notice produite par INIST R0xJtk31. Diffusion soumise à autorisation]. Background Fibrinogen and factor VII activity are known to be related to atherosclerosis and coronary heart disease, but population differences in clotting factors and modifiable characteristics that influence their levels have not been widely explored. Methods This paper examines correlates of plasma fibrinogen concentration and factor VII activity in 2443 men and women aged 35-64 in random samples selected from the residents in two districts in urban Warsaw (618 men and 651 women) and from rural Tarnobrzeg Province (556 men and 618 women) screened in 1987-1988, and assesses which characteristics might explain urban-rural differences. Fibrinogen and factor VII activity were determined using coagulation methods. Results Fibrinogen was 12.9 mg/dl higher in men and 14.1 mg/dl higher in women in Tarnobrzeg compared to Warsaw. Factor VII activity was higher in Warsaw (9.2% in men and 15.3% in women). After adjustment for selected characteristics, fibrinogen was higher in smokers compared to non-smokers by 28 mg/dl in men and 22 mg/dl in women. In women, a 15 mg/dl increase in HDL-cholesterol was associated with a 10 mg/dl decrease in fibrinogen (P<0.01). After adjustment for other variables, a higher factor VII activity in Warsaw remained significant (a difference of 9.4% in men and 14.8% in women). Lower fibrinogen in Warsaw remained significant only in women (15.4 mg/dl difference). (...) |
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