Résumé :
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[BDSP. Notice produite par INIST R0xBgl90. Diffusion soumise à autorisation]. Context. - The Lifestyle Heart Trial demonstrated that intensive lifestyle changes may lead to regression of coronary atherosclerosis after 1 year. Objectives. - To determine the feasibility of patients to sustain intensive lifestyle changes for a total of 5 years and the effects of these lifestyle changes (without lipid-lowering drugs) on coronary heart disease. Design. - Randomized controlled trial conducted from 1986 to 1992 using a randomized invitational design. Patients. - Forty-eight patients with moderate to severe coronary heart disease were randomized to an intensive lifestyle change group or to a usual-care control group, and 35 completed the 5-year follow-up quantitative coronary arteriography. Setting. - Two tertiary care university medical centers. Intervention. - lntensive lifestyle changes (10% fat whole foods vegetarian diet, aerobic exercise, stress management training, smoking cessation, group psychosocial support) for 5 years. Main Outcome Measures. - Adherence to intensive lifestyle changes, changes in coronary artery percent diameter stenosis, and cardiac events. Results. - Experimental group patients (20 [71% ] of 28 patients completed 5-year follow-up) made and maintained comprehensive lifestyle changes for 5 years, whereas control group patients (15 [75% ] of 20 patients completed 5-year follow-up) made more moderate changes. In the experimental group, the average percent diameter stenosis at baseline decreased 1. (...)
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