| Titre : | Sexual and non-sexual intrafamilial spread of hepatitis C virus : Intrafamilial transmission of HCV. (1998) |
| Auteurs : | N. SALTOGLU ; R. BURGUT ; I.H. DUNDAR ; Y. TASOVA ; Department of Biostatistics. Faculty of Medicine. University of Cukurova. Adana. TUR |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 14, n° 3, 1998) |
| Pagination : | 225-228 |
| Langues: | Anglais |
| Mots-clés : | Hépatite virale C ; Virose ; Infection ; Famille ; Homme ; Prévalence ; Virus ; Appareil digestif [pathologie] ; Foie [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST Nr10aR0x. Diffusion soumise à autorisation]. The rate of intrafamilial transmission of the hepatitis C virus (HCV) was investigated in 90 family members of 41 index patients with type C chronic liver disease. Antibody to HCV (anti-HCV) was detected by the EIA method (Abbott-Axsym Sys) and Hepatitis C virus RNA, by the polymerase chain reaction (Nested PCR). We also investigated the presence of anti-HCV in 350 healthy persons (control group). The subjects in the study included 38 spouses. 45 children and others (1 relative and 6 parents). Four family members including 3/38 (7.8%) spouses and 1 sister were found to be positive for anti HCV antibodies but none had HCV RNA. Anti-HCV was not detected in the children of index patients. The prevalence of anti-HCV in the families of index patients was significantly higher than in the controls (4.3% versus 0.85%) (p=0.0355). We concluded that the intrafamilial transmission of HCV is possible but occurs at a low rate. |
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