| Titre : | Spectrum of AIDS-associated malignant disorders. (1998) |
| Auteurs : | J.J. GOEDERT ; R.J. BIGGAR ; T.R. COTE ; M.H. GAIL ; E.S. JAFFE ; D.W. KINGMA ; S.M. SCOPPA ; P. VIRGO ; Aids-Cancer Match Study Group. INC ; Laboratory of Pathology. National Cancer Institute. Bethesda. USA ; Viral Epidemiology Branch. National Cancer Institute. Rockville. USA |
| Type de document : | Article |
| Dans : | Lancet (The) (vol. 351, n° 9119, 1998) |
| Pagination : | 1833-1839 |
| Langues: | Anglais |
| Mots-clés : | Sida ; Virose ; Infection ; VIH ; Rétrovirus ; Virus ; Association ; Dépistage ; Facteur risque ; Homme ; Etats Unis ; Amérique du Nord ; Amérique ; Porto Rico ; Antilles ; Amérique centrale ; Immunopathologie ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST 15pR0xkC. Diffusion soumise à autorisation]. Background To clarify which types of cancer result from AIDS, we compared the cancer experiences of people with AIDS with those of the general population by matching population-based cancer and AIDS registries in the USA and Puerto Rico. Methods We used a probabilistic matching algorithm to compare names, birth dates, and, where available, social-security numbers of 98336 people with AIDS and 1125 098 people with cancer aged less than 70 years. We defined AIDS-related cancers as those with both significantly raised incidence post-AIDS and increasing prevalence from 5 years pre-AIDS to 2 years post-AIDS. Findings Among people with AIDS, we found 7028 cases of Kaposi's sarcoma (KS), 1793 of non-Hodgkin lymphoma (NHL), and 712 other cases of histologically defined cancer. Incidence rates among people with AIDS were increased 310-fold for KS, 113-fold for NHL, and 1.9-fold (95% CI 1.5-2.3) for other cancers. Of 38 malignant disorders other than KS and NHL, only angiosarcoma (36.7-fold), Hodgkin's disease (7.6-fold), multiple myeloma (4.5-fold), brain cancer (3.5-fold), and seminoma (2.9-fold) were raised and increasing significantly (p<0.02) from the pre-AIDS to the post-AIDS period. Interpretation Interpretation is complicated by screening and shared risk factors, such as sexual behaviour and cigarette smoking. However, our data indicate that AIDS leads to a significantly increased risk of Hodgkin's disease, multiple myeloma, brain cancer, and seminoma. (...) |
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