| Titre : | Persistence of use of lipid-lowering medications : A cross-national study. (1998) |
| Auteurs : | J. AVORN ; R.L. BOHN ; A. LACOUR ; M.J. LELORIER ; H. MOGUN ; M. MONANE ; J. MONETTE ; Centre de Recherche. Hôtel-Dieu de Montréal. Université de Montréal. Montreal Quebec. CAN ; Division of Pharmacoepidemiology and Pharmacoeconomics. Department of Medicine. Brigham and Women's Hospital. Harvard Medical School. Boston Mass. USA |
| Type de document : | Article |
| Dans : | JAMA - Journal of the american medical association (vol. 279, n° 18, 1998) |
| Pagination : | 1458-1462 |
| Langues: | Anglais |
| Mots-clés : | Statistique ; Thérapeutique médicamenteuse ; Thérapeutique ; Homme ; Canada ; Amérique du Nord ; Amérique ; Etats Unis ; Lipide ; Métabolisme [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST y93R0x4Z. Diffusion soumise à autorisation]. Context. - Although clinical trials have demonstrated the benefits of lipid-lowering therapy, little is known about how these drugs are prescribed or used in the general population. Objective. - To estimate predictors of persistence with therapy for lipid-lowering drug regimens in typical populations of patients in the United States and Canada. Design. - A cohort study defining all prescriptions filled for lipid-lowering drugs during 1 year, as well as patients'demographic and clinical characteristics. Setting. - New Jersey's Medicaid and Pharmacy Assistance for the Aged and Disabled programs and Quebec's provincial medical care program. Patients. - All continuously enrolled patients older than 65 years who filled 1 or more prescriptions for lipid-lowering-drugs (N=5611 in the US programs, and N=1676 drawn from a 10% sample in Quebec). Main Outcome Measures. - Proportion of days during the study year for which patients had filled prescriptions for lipid-lowering drugs ; predictors of good vs poor persistence with therapy. Results. - In both populations, patients failed to fill prescriptions for lipid-lowering drugs for about 40% of the study year. Persistence rates with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors were significantly higher than those seen with cholestyramine (64.3% vs 36.6% of days with drug available, respectively). (...) |
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