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Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease.

Donald-J LEHMANN ; CORTINA-BORJA (Mario) : GBR. Centre for Paediatric Epidemiology and Biostatistics. Institute of Child Health. University College London. London. ; KEHOE (Patrick-G) : GBR. Care of the Elderly. Department of Clinical Science at North Bristol. University of Bristol. Frenchay Hospital. Bristol. ; PRINCE (Jonathan-A) : SWE. Center for Genomics and Bioinformatics. Karolinska Institute. Stockholm. ; Kristel SLEEGERS ; Adavid Smith ; Cornelia-M VAN DUIJN ; Donald-R WARDEN ; Erasmus Mc. Department of Epidemiology and Biostatistics. Rotterdam. NLD ; University of Oxford. Department of Pharmacology. Oxford Project to Investigate Memory and Ageing. (O.P.T.I.M.A.). Oxford. GBR |

Dans American journal of epidemiology (vol. 162, n° 4, 2005)

[BDSP. Notice produite par INIST-CNRS XWlR0xjG. Diffusion soumise à autorisation]. Apolipoprotein E epsilon4 (APOE*4) is the only fully established susceptibility allele for Alzheimer's disease. One of the most studied candidates is the insertio[...]

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