| Titre : | Gastrointestinal symptoms following consumption of olestra or regular triglyceride potato chips : A controlled comparison. (1998) |
| Auteurs : | L.J. CHESKIN ; T. FILLOON ; R. MIDAY ; N. ZORICH ; Regulatory and Clinical Development Division. Procter & Gamble Company. Cincinnati Ohio. USA |
| Type de document : | Article |
| Dans : | JAMA - Journal of the american medical association (vol. 279, n° 2, 1998) |
| Pagination : | 150-152 |
| Langues: | Anglais |
| Mots-clés : | Triglycéride ; Alimentation ; Homme |
| Résumé : | [BDSP. Notice produite par INIST j42zvR0x. Diffusion soumise à autorisation]. Context. - Clestra, a nonabsorbable, energy-free fat substitute used in snack foods, has been anecdotally reported to cause gastrointestinal (GI) adverse events, although such effects were not expected based on results from randomized trials, in which it was consumed in typical snack patterns. Objective. - To determine whether ad libitum consumption of potato chips made with the fat substitute olestra results in a different level of Gl symptoms than regular chips made with triglyceride (TG). Design. Randomized, double-blind, parallel, placebo-controlled trial. Setting. - A suburban Chicago, III, multiplex cinema. Subjects. - A total of 1123 volunteers aged 13 to 88 years. Intervention. - Subjects were given a beverage and an unlabeled, white 369-g (13-oz) bag of potato chips made with olestra or TG during a free movie screening. Main Outcome Measures. - Total and specific GI symptoms reported during a telephone interview conducted from 40 hours to 10 days after ingestion ; level of potato chip consumption ; and satiety level. Results. - Of 563 evaluable subjects in the olestra chip group, 89 (15.8%) reported 1 or more Gl symptoms, while 93 (17.6%) of the 529 evaluable subjects in the regular TG chip group did so (difference in symptom frequency between olestra and TG, - 1.8 ; 95% confidence interval, - 6.2 to 2.7 ; P=47). For specific GI symptoms (eg, gas, diarrhea, abdominal cramping), there were no significant differences between olestra and TG chips. (...) |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact