| Titre : | Risk factors for 5-year mortality in older adults : The cardiovascular health study. (1998) |
| Auteurs : | L.P. FRIED ; D.E. BILD ; J.M. GARDIN ; R.A. KRONMAL ; Maurice B. Mittelmark ; A.B. NEWMAN ; J.F. POLAK ; J.A. Robbins ; Cardiovascular Health Study Collaborative Research Group. INC |
| Type de document : | Article |
| Dans : | JAMA - Journal of the american medical association (vol. 279, n° 8, 1998) |
| Pagination : | 585-592 |
| Langues: | Anglais |
| Mots-clés : | Grand âge ; Homme ; Dépistage ; Facteur risque ; Létalité ; Evaluation |
| Résumé : | [BDSP. Notice produite par INIST R0xCAjn0. Diffusion soumise à autorisation]. Context. - Multiple factors contribute to mortality in older adults, but the extent to which subclinical disease and other factors contribute independently to mortality risk is not known. Objective. - To determine the disease, functional, and personal characteristics that jointly predict mortality in community-dwelling men and women aged 65 years or older. Design. - Prospective population-based cohort study with 5 years of follow-up and a validation cohort of African Americans with 4.25-year follow-up. Setting. - Four US communities. Participants. - A total of 5201 and 685 men and women aged 65 years or older in the original and African American cohorts, respectively. Main Outcome Measures. - Five-year mortality. Results. - In the main cohort, 646 deaths (12%) occurred within 5 years. Using Cox proportional hazards models, 20 characteristics (of 78 assessed) were each significantly (P<. 05) and independently associated with mortality : increasing age, male sex, income less than $50 000 per year, low weight, lack of moderate or vigorous exercise, smoking for more than 50 pack-years, high brachial (>169 mm Hg) and low tibial ( 127 mm Hg) systolic blood pressure, diuretic use by those without hypertension or congestive heart failure, elevated fasting glucose level (>7.2 mmol/L [130 mg/dL]), low albumin level ( 37 g/L), elevated creatinine level ( 106 mumol/L [1.2 mg/dL]), low forced vital capacity. (...) |
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