Changes in T cell subpopulations in lead workers. Catalogue en ligne

Titre :	Changes in T cell subpopulations in lead workers. (1998)
Auteurs :	F. SATA ; S. ARAKI ; N. KATSUNO ; Y. MORITA ; A. NAKATA ; S. SAKURAI ; T. TANIGAWA ; Department of Public Health. Faculty of Medicine. University of Tokyo. Bunkyo ku Tokyo. JPN
Type de document :	Article
Dans :	Environmental research (vol. 76, n° 1, 1998)
Pagination :	61-64
Langues:	Anglais
Mots-clés :	Plomb ; Exposition professionnelle ; Médecine travail ; Homme ; Immunopathologie
Résumé :	[BDSP. Notice produite par INIST R0xuq1wp. Diffusion soumise à autorisation]. To investigate the effects of lead on the human immune system, we analyzed T cell subpopulations and B (CD19+) cells in peripheral blood in 71 male lead workers. They were engaged in manufacturing lead stearate in a chemical factory, aged 20 to 74 (mean 48) years. Their blood lead concentrations (PbB) were between 7 and 50 (mean 19) mug/dl. The control group consisted of 28 "healthy" male volunteers without a history of occupational exposure to lead or other hazardous substances, aged 33 to 67 (mean 55) years. In comparison with the controls, a significant reduction in the number of CD3+CD45RO+ (memory T) cells and a significant expansion in the percentage of CD8+cells in the lead workers were found. There was a significant positive correlation between the percentage of CD3+CD45RA+ (naive T) cells and PbB in the lead workers. It is suggested that CD45RO+memory T cells may be most susceptible to the effects of lead on T cell subpopulations.

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