| Titre : | Predictors of sex hormone levels among the elderly : A study in Greece. (1998) |
| Auteurs : | C.C. HSIEH ; P. LAGIOU ; L. LIPWORTH ; C.S. MANTZOROS ; L.B. SIGNORELLO ; D. TRICHOPOULOS ; Department of Epidemiology and Harvard Center for Cancer Prevention. Harvard School of Public Health. Boston. MA. USA |
| Type de document : | Article |
| Dans : | Journal of clinical epidemiology (vol. 51, n° 10, 1998) |
| Pagination : | 837-841 |
| Langues: | Anglais |
| Mots-clés : | Age ; Condition vie ; Poids corporel ; Epidémiologie ; Taux ; Plasma sanguin ; Homme ; Grèce ; Europe |
| Résumé : | [BDSP. Notice produite par INIST oMR0xA5O. Diffusion soumise à autorisation]. This study examines the relationship between a series of epidemiologic parameters (age, height, body mass index (BMI), smoking, alcohol consumption, and coffee drinking) and serum concentrations of testosterone, estradiol, sex hormone-binding globulin (SHBG), and dehydroepiandrosterone sulfate (DHEAS). Among 52 healthy, elderly Greek men, we observed that serum levels of DHEAS decreased with increasing age [19% decline per 5-year increase in age, 95% CI, - 2.1--33.5], obesity [48% decline for BMI>30 kg/m2 compared to<27 kg/m2, Cl, - 15.7--68.7], and current smoking [37% decline compared to nonsmokers, Cl, - 9.5--57.2]. Estradiol concentrations increased with increasing BMI [77.1% increase for BMI>30 kg/m2 compared to<27 kg/m2, Cl, - 12.0-256.3], alcohol drinking [66% increase for >=7 glasses/week compared to<7 glasses/week, Cl, 4.4-164.4], and coffee drinking [59% increase for >=14 cups/week compared to >=14 cups/week, Cl, - 0.5-155.9], and decreased among current smokers [40% decline compared to nonsmokers, CI, - 64.9-0.8]. SHBG was marginally positively associated with increasing age [13% increase per 5 years, CI, - 0.5-29.6]. Testosterone was significantly related only to current smoking [27% decline compared to nonsmokers, CI, - 45.4--3.1]. These findings suggest that several variables appear to be associated with sex steroid levels and the influence of these findings on the occurrence of hormone-related conditions warrants further exploration. |
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