| Titre : | Weight history, glucose intolerance, and insulin levels in middle-aged Swedish men. (1998) |
| Auteurs : | S. CARLSSON ; M. ALVARSSON ; S. EFENDIC ; V. GRILL ; A. NORMAN ; C.G. OSTENSON ; P.G. PERSSON ; L. SVANSTROM ; Department of Molecular Medicine. Karolinska Institutet. Stockholm. SWE ; Department of Public Health Sciences. Division of Social Medicine. Karolinska Institutet. Stockholm. SWE ; Department of Social Medicine. Stockholm County Council. Stockholm. SWE ; Division of Epidemiology. Karolinska University Hospital. Stockholm. SWE |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 148, n° 6, 1998) |
| Pagination : | 539-545 |
| Langues: | Anglais |
| Mots-clés : | Obésité ; Poids corporel ; Diabète ; Insuline ; Taux ; Plasma sanguin ; Epidémiologie ; Facteur risque ; Adulte ; Homme ; Suède ; Europe ; Maladie nutrition ; Glande endocrine [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST iUOYTR0x. Diffusion soumise à autorisation]. The association between weight history and glucose intolerance was examined in a cross-sectional study consisting of 3,128 Swedish men aged 35-56 years, 52 percent of whom had a family background of diabetes mellitus. Oral glucose tolerance testing detected 55 cases of type 2 (non-insulin-dependent) diabetes and 172 cases of impaired glucose tolerance. Among men with no family history of diabetes, the estimated odds ratios for impaired glucose tolerance associated with short (<5 years) and long ( 10 years) durations of obesity (body mass index (weight (kg)/height2 (m2) 25.0) were 1.3 (95% confidence interval (Cl) 0.2-7.7) and 11.8 (95% Cl 3.3-41.9), respectively. Among men with a family history of diabetes, the odds ratios were 2.0 (95% Cl 0.8-4.7) and 4.0 (95% Cl 1.8-9.1), respectively. Corresponding estimates of the odds of type 2 diabetes, adjusted for family history of diabetes, were 1.9 (95% Cl 0.5-7.1) and 7.3 (95% Cl 2.2-23.7), respectively. The odds of high ( 30.0 mU/liter) fasting insulin levels in subjects with impaired glucose tolerance were 6.9 (95% Cl 0.6-74.2) and 21.0 (95% Cl 2.1-206.4) for short and long durations of obesity, respectively. Corresponding estimated odds of low 2-hour insulin response (<=71.9 mU/liter) were 0.7 (95% Cl 0.2-2.9) and 3.3 (95% Cl 1.2-8.9). Homeostasis model assessment of insulin resistance yielded an odds ratio of 6.7 (95% Cl 0.6-73.4) for a short duration of obesity and 20.0 (95% Cl 2.0-200.6) for a long duration. (...) |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact