| Titre : | The quest for "power" : Contradictory hypotheses and inflated sample sizes. (1998) |
| Auteurs : | A.R. FEINSTEIN ; J. CONCATO ; Department of Medicine. Yale University School of Medicine. New Haven Connecticut. USA |
| Type de document : | Article |
| Dans : | Journal of clinical epidemiology (vol. 51, n° 7, 1998) |
| Pagination : | 537-545 |
| Langues : | Anglais |
| Mots-clés : | Essai thérapeutique ; Epidémiologie ; Méthodologie ; Evaluation ; Homme |
| Résumé : | [BDSP. Notice produite par INIST eYiQR0xu. Diffusion soumise à autorisation]. To have the "power'of avoiding undersized clinical trials, the customary statistical strategy used in the past few decades is aimed at rejecting both a null stochastic hypothesis and a contradictory alternative hypothesis. This approach gives a trial the" power'to confirm the "insignificance'of differences much smaller than the large value of delta desired in trials done to show efficacy, In many instances, however, a prime problem is that the current" double-significance'approach produces sample sizes 2-3 times larger than needed for stochastic confirmation of large differences ( delta). The inflated sample sizes and consequent problems can be avoided if a realistic value for delta is chosen and maintained thereafter, and if an adequate "capacity'is calculated for" single significance. ". |
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