| Titre : | Doses and models in risk assessment analysis for bronchial hyperresponsiveness. (1998) |
| Auteurs : | R. DE MARCO ; M. BUGIANI ; B. RIJCKEN ; G. VERLATO ; E. ZANOLIN ; Cattedra di Statistica Medica e Biometria. UniversitA di Verona. Verona. ITA |
| Type de document : | Article |
| Dans : | Journal of clinical epidemiology (vol. 51, n° 1, 1998) |
| Pagination : | 19-28 |
| Langues: | Anglais |
| Mots-clés : | Poumon ; Asthme ; Dose effet ; Facteur risque ; Survie ; Epidémiologie ; Homme ; Appareil respiratoire [pathologie] ; Bronchopneumopathie obstructive |
| Résumé : | [BDSP. Notice produite par INIST QR0x9OEt. Diffusion soumise à autorisation]. The aims of this study are : (1) to evaluate whether the estimates of the association of risk factors with bronchial hyperresponsiveness (BHR) depends on the accumulated dose administered in challenge tests ; and (2) to verify whether a model developed for survival studies (Weibull regression) is suited to analyze methacholine dose-response curves. For these purposes, 863 challenge tests, from EC Respiratory Health Survey in Italy, up to a cumulative dose of 6 mg methacholine, were analyzed by Weibull regression and by traditional methods (logistic model and linear model), both before and after truncation of the curves at 2 mg. With all methods the main risk factors for BHR were respiratory symptoms and atopy while age and airway caliber exerted a protective action. Our results confirmed that in epidemiological surveys 2 mg methacholine is enough to fully appreciate the effect of risk factors on BHR and showed that the Weibull model explains the observed variability better than linear and logistic regressions. |
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