| Titre : | Risk factors for lung cancer in young adults. (1998) |
| Auteurs : | M. KREUZER ; I. BRUSKE-HOHLFELD ; M. GERKEN ; J. HEINRICH ; L. KREIENBROCK ; K.M. MULLER ; H.E. WICHMANN ; Institute of Epidemiology. Gsf-National Research Center for Environment and Health. Neuherberg. DEU |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 147, n° 11, 1998) |
| Pagination : | 1028-1037 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Tabagisme ; Epidémiologie ; Facteur risque ; Jeune adulte ; Homme ; Grand âge ; Allemagne ; Europe ; Appareil respiratoire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST 9ECDDR0x. Diffusion soumise à autorisation]. Risk factors for early onset of lung cancer are relatively unknown. In a case-control study, carried out in Germany between 1990 and 1996, the effects of smoking and familial aggregation of cancer were compared in 251 young cases and 280 young controls (<45 years) and in 2,009 older cases and 2,039 older controls (55-69 years). The male/female ratio was 2.6/1 in young patients and 5.6/1 in older patients. Adenocarcinomas were more frequent in young men than in older men (41% vs. 28%). Duration of smoking and amount smoked showed significantly increased odds ratios for lung cancer in both age groups. Lung cancer in a first degree relative was associated with a 2.6-fold (95% confidence interval (Cl) 1.1-6.0) increase in the risk of lung cancer in the young age group, but no elevated risk was seen in the older group (OR=1.2,95% Cl 0.9-1.6). Smoking-related cancer in relatives with the age at diagnosis under 46 years was associated with an increased risk of lung cancer in the young group (OR=5.6,95% Cl 0.7-46.9) but not in the older group (OR=0.7,95i6 Cl 0.3-1.5). Results indicated that lung cancer risk in young and older age groups shows remarkable differences with respect to sex, histologic type, and genetic predisposition. |
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