| Titre : | Adverse lipid and coronary heart disease risk profiles in young women with polycystic ovary syndrome : Results of a case-control study. (1998) |
| Auteurs : | E. TALBOTT ; S.L. BERGA ; A. CLERICI ; T. DANIELS ; K. DETRE ; R.A. ENGBERG ; D. GUZICK ; L. KULLER ; Department of Epidemiology. Graduate School of Public Health. University of Pittsburgh. Pittsburgh Pennsylvania. USA ; Department of Obstetrics. Gynecology and Reproductive Sciences. School of Medicine. University of Pittsburgh. Magee-Womens Hospital. Pittsburgh Pennsylvania. USA |
| Type de document : | Article |
| Dans : | Journal of clinical epidemiology (vol. 51, n° 5, 1998) |
| Pagination : | 415-422 |
| Langues: | Anglais |
| Mots-clés : | Cardiopathie coronaire ; Epidémiologie ; Facteur risque ; Femme ; Homme ; Jeune adulte ; Etats Unis ; Amérique du Nord ; Amérique ; Lipide ; Appareil circulatoire [pathologie] ; Métabolisme [pathologie] ; Tumeur bénigne ; Kyste |
| Résumé : | [BDSP. Notice produite par INIST UPR0xA4J. Diffusion soumise à autorisation]. Polycystic ovary syndrome (PCOS), a disorder of hyperandrogenism and chronic anovulation affects 5% - 10% of all women. Women with PCOS often have elevated cardiovascular risk factors. A total of 244 PCOS cases were identified through the Division of Reproductive Endocrinology at Magee-Womens Hospital and were age-matched to 244 neighborhood controls. The average age of cases and controls was 35.3 7.4 and 36.7 7.7. Women with PCOS compared to controls had substantially higher LDL-C and total cholesterol levels at each age group under 45 years after adjustment for body mass index, hormone use, and insulin levels. In the over 40-year age group, little difference was noted between cases and controls. Among cases and controls (<40), PCOS predicted LDL-C, total cholesterol and triglycerides, but did not have a significant effect on lipid levels in older cases and controls after controlling for the other variables. The primarily pre-to perimenopausal PCOS cases 40 years of age have similar LDL-C and total cholesterol levels as their age-matched controls, probably reflecting the LDL-C increase with age among controls. |
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