| Titre : | Menstrual cycle characteristics and history of ovulatory infertility in relation to breast cancer risk in a large cohort of US women. (1998) |
| Auteurs : | M. GARLAND ; G.A. COLDITZ ; D.J. HUNTER ; J.E. MANSON ; F. SPEIZER ; D. SPIEGELMAN ; M.J. STAMPFER ; W.C. Willett ; Channing Laboratory. Department of Medicine. Harvard Medical School and Brigham and Women's Hospital. Boston MA. USA ; Department of Epidemiology. Harvard School of Public Health. Boston MA. USA ; Department of Nutrition. Harvard School of Public Health. Boston MA. USA ; Harvard Center for Cancer Prevention. Harvard School of Public Health. Boston MA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 147, n° 7, 1998) |
| Pagination : | 636-643 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Sein ; Stérilité ; Epidémiologie ; Facteur risque ; Homme ; Femme ; Etats Unis ; Amérique du Nord ; Amérique ; Glande mammaire [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST b3R0xDX7. Diffusion soumise à autorisation]. Menstrual cycle characteristics and ovulatory infertility were evaluated in relation to breast cancer risk among 116,678 women in the Nurses'Health Study II, a prospective cohort study of female registered nurses who were aged 25-42 years and living in 14 US states at enrollment in 1989. During 396,299 person-years of follow-up between return of the baseline questionnaire and June 1993,251 cases of breast cancer were identified in this cohort. The multivariate relative risk (RR) associated with age at menarche>13 years compared with age <=12 years was 0.66 (95% confidence interval (Cl) 0.44-0.99). Short and long menstrual cycle lengths at ages 18-22 years were associated with reduced risk. Compared with menstrual cycle length 26-31 days, the multivariate relative risks (95% Cls) for more extreme cycle lengths were :<26 days, 0.50 (0.25-0.98) ; 32-39 days, 0.81 (0.51-1.28) ; and>39 days or too irregular for estimation of a usual cycle length, 0.41 (0.18-0.94). The multivariate relative risk associated with a history of ovulatory infertility, compared with no such history, was 0.41 (95% Cl 0.180.93). These results are consistent with the hypothesis that reduced exposure to ovulatory menstrual cycles provides a protective effect against breast cancer. |
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