| Titre : | Polychlorinated biphenyls in blood plasma among Swedish female fish consumers in relation to low birth weight. (1998) |
| Auteurs : | L. RYLANDER ; E. DYREMARK ; L. HAGMAR ; P. NILSSON-EHLE ; C. OSTMAN ; U. STROMBERG ; Department of Occupational and Environmental Medicine. Institute of Laboratory Medicine. University Hospital. Lund. SWE ; Division of Analytical Chemistry. National Institute for Working Life. Solna. SWE |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 147, n° 5, 1998) |
| Pagination : | 493-502 |
| Langues: | Anglais |
| Mots-clés : | Intoxication ; Alimentation ; Incidence ; Epidémiologie ; Toxicomane ; Homme ; Toxicomanie ; Nutrition ; Gestation [pathologie] ; Prématurité |
| Résumé : | [BDSP. Notice produite par INIST R0xYTbBo. Diffusion soumise à autorisation]. The authors examined the hypothesized association between the body burden of polychlorinated biphenyls (PCB) in women and the risk of low birth weight for their infants. In Sweden, a main exposure route for PCBs and other persistent organochlorine compounds is through the consumption of fatty fish from the Baltic Sea (on the Swedish east coast). A previous comparison between a cohort of consumers of large quantities of fish from the Swedish east coast and a reference population, together with a following analysis based on questionnaire data from a case-control study within the east coast cohort, supported the hypothesized association. In 1995, blood samples were collected from the wives and ex-wives of fishermen from the Swedish east coast (n=192) who had given birth during the period 1973-1991. Cases (n=57), i.e., infants with low birth weight (1,500-2,750 g), were matched with controls (n=135 ; birth weight, 3,250-4,500 g) on gender, parity, and calendar year of birth. The concentration of 2,2'4,4'5,5'-hexachlorobiphenyl (CB-153) in plasma was analyzed ; it has been suggested that CB-153 is a relevant biomarker of exposure to PCBs. The concentration of CB-153 in the plasma of mothers during the year of childbirth was "estimated" using some alternative plausible kinetic models. (...) |
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