| Titre : | Epidemiological evidence for the disruption of ionized calcium homeostasis in the elderly. (1997) |
| Auteurs : | J.B. WATSON ; R. Klein ; B.E.K. KLEIN ; D.D. KOCH ; K. LEE ; Department of Ophthalmology. University of Wisconsin-Madison. Madison Wisconsin. USA ; Department of Pathology and Laboratory Medicine. University of Wisconsin-Madison. Madison Wisconsin. USA |
| Type de document : | Article |
| Dans : | Journal of clinical epidemiology (vol. 50, n° 7, 1997) |
| Pagination : | 845-849 |
| Langues: | Anglais |
| Mots-clés : | Ostéoporose ; Calcium ; Sexe ; Age ; Epidémiologie ; Facteur risque ; Homme ; Etats Unis ; Amérique du Nord ; Amérique ; Système ostéoarticulaire [pathologie] ; Ostéopathie |
| Résumé : | [BDSP. Notice produite par INIST 0heR0xBg. Diffusion soumise à autorisation]. Ionized calcium (Ca2+), phosphate, albumin, total calcium, and pH measurements taken from participants in a large population-based epidemiological study were examined to determine the change in physiological variation with age for persons over 43 years old. Only Ca2+showed a statistically significant increase in SD with age (p<0.0001). The Ca 2+coefficients of variation (CV) increased from 2.92% in the youngest age group (43-54 years) to 3.69% in the oldest age group (75-86 years of age). In females, the increase in Ca2+variability was nearly complete by age 55. Males also showed a significant (p=0.006) increase in SD between the 43-54 age group and the 55-64 age group, however, Ca2+variability did not plateau after age 55 in men as it did in women. In the 43-54 (p=0.04) and 55-64 (p=0.03) age group men showed significantly better physiological control of Ca+than women. Phosphate showed a slight decrease in CV with age. These data suggest that Ca2+homeostasis is disrupted in the same age groups that are most vulnerable to osteoporosis. |
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