| Titre : | Determinants of gamma-glutamyltransferase : Positive interaction with alcohol and body mass index, negative association with coffee. (1997) |
| Auteurs : | K. POIKOLAINEN ; E. VARTIAINEN ; National Public Health Institute. Helsinki. FIN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 146, n° 12, 1997) |
| Pagination : | 1019-1024 |
| Langues: | Anglais |
| Mots-clés : | Enzyme ; Alcool ; Café ; Finlande ; Europe ; Tabagisme ; Obésité ; Marqueur tabagisme ; Adulte ; Homme ; Maladie nutrition |
| Résumé : | [BDSP. Notice produite par INIST FUrTLR0x. Diffusion soumise à autorisation]. gamma-Glutamyltransferase is widely used as a marker of alcohol intake although its performance is poor. This might be related to other conditions influencing gamma-glutamyltransferase activity. The authors studied determinants of gamma-glutamyltransferase activity in a random sample (n=6,010) drawn from the general population aged 25-64 years in Finland in 1992. In regression analysis, coffee intake and drinking boiled coffee were significantly (p<0.01) negatively related to y-glutamyltransferase, whereas age, male gender, the number of cigarettes per day, serum total cholesterol and high density lipoprotein cholesterol, heart rate, and diastolic blood pressure were significantly positively related to gamma-glutamyltransferase. A significant (p=0.02) positive interaction was observed between alcohol intake and body mass index. In logistic regression analysis, the proportion of elevated gamma-glutamyltransferase values ( 50 U/liter) was significantly decreased, compared with lifelong abstainers, at the alcohol intake level of<40 g/week (odds ratio (OR)=0.51,95% confidence interval (Cl) 0.29-0.92) and significantly increased at the level of 300 g/week (OR=2.81,95% Cl 1.35-5.85) among nonobese subjects (body mass index<27 kg/m2). Among obese subjects, the respective proportion was significantly increased at the alcohol intake level of 40 g/week (OR=2.02,95% Cl 1.11-3.68). (...) |
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