Titre :
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Sample size requirements in case-only designs to detect gene-environment interaction. (1997)
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Auteurs :
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Q. YANG ;
W.D. FLANDERS ;
M.J. KHOURY
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 146, n° 9, 1997)
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Pagination :
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713-720
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Langues:
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Anglais
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Mots-clés :
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Epidémiologie
;
Méthodologie
;
Homme
;
Etiologie
;
Génétique
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Résumé :
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[BDSP. Notice produite par INIST 0R0xPSRK. Diffusion soumise à autorisation]. With advances in molecular genetic technology, more studies will examine gene-environment interaction in disease etiology. If the primary purpose of the study is to estimate the effect of gene-environment interaction in disease etiology, one can do so without employing controls. The case-only design has been promoted as an efficient and valid method for screening for gene-environment interaction. The authors derive a method for estimating sample size requirements, present sample size estimates, and compare minimum sample size requirements to detect gene-environment interaction in case-only studies with case-control studies. Assuming independence between exposure and genotype in the population, the authors believe that the case-only design is more efficient than a case-control design in detecting gene-environment interaction. They also illustrate a method to estimate sample size when information on marginal effects (relative risk) of exposure and genotype is available from previous studies.
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