| Titre : | Low insulin sensitivity is associated with clustering of cardiovascular disease risk factors. (1997) |
| Auteurs : | L. MYKKANEN ; R.N. BERGMAN ; S.M. HAFFNER ; M. LAAKSO ; T. RONNEMAA ; Department of Medicine. University of Kuopio. Kuopio. FIN ; Division of Clinical Epidemiology. Department of Medicine. University of Texas Health Science Center at San Antonio. San Antonio TX. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 146, n° 4, 1997) |
| Pagination : | 315-321 |
| Langues: | Anglais |
| Mots-clés : | Diabète ; Plasma sanguin ; Hypertension artérielle ; Hyperglycémie provoquée ; Obésité ; Appareil circulatoire [pathologie] ; Epidémiologie ; Facteur risque ; Homme ; Finlande ; Europe ; Insuline ; Lipide ; Glucose ; Etude comparée ; Glande endocrine [pathologie] ; Métabolisme [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST 5t4oR0xL. Diffusion soumise à autorisation]. Hyperinsulinemia is associated with multiple metabolic disorders including high triglyceride level, low high density lipoprotein (HDL) cholesterol level, hypertension, and impaired glucose tolerance (IGT). This metabolic constellation is also called the insulin resistance syndrome. All previous data on clustering of these risk factors are, however, based on insulin levels. Therefore, the authors examined the association of insulin sensitivity estimated by means of a frequently sampled intravenous glucose tolerance test and the minimal model with the number of metabolic disorders (dyslipidemia [high triglyceride level or low HDL cholesterol level or both], hypertension, and IGT according to the World Health Organization criteria). Of 153 nondiabetic subjects aged 53-61 years who had participated in a previous population-based study, 79 had no disorders, 55 had one disorder, 16 had two disorders, and 3 had three disorders. Insulin sensitivity index (SI) decreased with the increasing number of disorders (4.1,3.5,1.8, and 1.4 x 10-4 min-1 muU-1 mL-1, in subjects with 0,1,2, and 3 disorders, respectively ; p<0.001 for trend). Similarly, fasting (7.5,7.8,15.3, and 22.0 muU/mL ; p<0.001) and 2-hour insulin levels (39.9,49.0,98.7, and 149.6 muU/mL ; p<0.001) increased by the increasing number of disorders. The relations of SI and fasting and 2-hour insulin levels with multiple metabolic disorders were independent of sex, obesity, and body fat distribution. (...) |
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