| Titre : | Insulin and endometrial cancer. (1997) |
| Auteurs : | R. TROISI ; L.A. BRINTON ; R.N. HOOVER ; N. POTISCHMAN ; P. SIITERI ; Environmental Epidemiology Branch. National Cancer Institute. Bethesda MD. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 146, n° 6, 1997) |
| Pagination : | 476-482 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Endomètre ; Taux ; Obésité ; Facteur risque ; Femme ; Homme ; Epidémiologie ; Etats Unis ; Amérique du Nord ; Amérique ; Insuline ; Utérus [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST P91ZkR0x. Diffusion soumise à autorisation]. Elevated insulin levels may explain part of the increased risk of endometrial cancer observed in obese postmenopausal women. Circulating sex hormones and fasting C-peptide levels were measured in sera obtained from 165 postmenopausal endometrial cancer cases accrued between June 1,1987, and May 15,1990, from hospitals in Chicago, Illinois ; Hershey, Pennsylvania ; Irvine and Long Beach, California ; Minneapolis, Minnesota ; and Winston-Salem, North Carolina, and 180 community and hysterectomy controls. Women with a personal history of diabetes were excluded. Among controls, C-peptide was positively correlated with body mass index (BMI) ( (r=0.44), waist-to-thigh circumference ratio ( (r=0.24), estrone ( (r=0.18), and estradiol ( (r=0.28) (albumin-bound (r=0.45), and free (r=0.37)) and negatively correlated with sex hormone-binding globulin (r=-0.48). In age-adjusted analyses, the odds ratios and 95% confidence intervals for tertiles of C-peptide and endometrial cancer were, from lowest to highest : 1.0 (reference), 0.78 (95% confidence interval (Cl) 0.43-1.4), and 2.2 (95% CI 1.3-3.7). Further adjustment for BMI substantially attenuated the odds ratios for the highest tertile of C-peptide (odds ratio=1.2,95% Cl 0.63-2.1), and adjustment for body mass index and other risk factors for endometrial cancer eliminated the association (odds ratio=1.0,95% Cl 0.55-2.0). (...) |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact