| Titre : | Epidemiology of Helicobacter pylori infection among 4742 randomly selected subjects from Northern Ireland. (1997) |
| Auteurs : | L.J. MURRAY ; K.B. BAMFORD ; A.E. EVANS ; E.E. MCCRUM ; Department of Epidemiology and Public Health. The Queen's University of Belfast. Mulhouse Building. Royal Group of Hospitals. Belfast Northern Ireland. GBR |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 26, n° 4, 1997) |
| Pagination : | 880-887 |
| Langues: | Anglais |
| Mots-clés : | Bactérie ; Infection ; Facteur socioéconomique ; Démographie ; Age ; Sexe ; Condition vie ; Tabagisme ; Consommation ; Boisson alcoolisée ; Epidémiologie ; Prévalence ; Facteur risque ; Homme ; Irlande ; Europe |
| Résumé : | [BDSP. Notice produite par INIST 6hR0xBhZ. Diffusion soumise à autorisation]. Background. Despite the widespread prevalence and serious clinical sequelae of infection with Helicobacter pylori, there have been few large population-based studies, using randomly selected subjects, examining the epidemiology of this infection. Aim. To examine the distribution and determinants of H. pylori infection in a developed country. Subjects and Setting. Overall 4742 subjects, aged 12-64, from Northern Ireland were randomly selected. Methods. Helicobacter pylori specific IgG antibodies were measured by enzyme linked immunosorbent assay, using an acid-glycine extract antigen, in stored serum from subjects who had participated in three linked population-based surveys of cardiovascular risk factors performed in 1986 and 1987. Results. The overall prevalence of H. pylori infection was 50.5%. Prevalence increased with age from 23.4% in 12-14 year olds to 72.7% in 60-64 year olds : X2 for trend 518, P<10-4. In subjects aged 25, infection was more common in males (60.9%) than females (55.2%) : X2=9.53, P<0.01. This relation remained significant after adjusting for age, and measures of socioeconomic class : odds ratio (OR) for infection, male versus female was 1.19 (95% confidence interval [CI] : 1.02-1.40). Infection was associated with social class : the adjusted OR of infection in subjects from manual social classes relative to those from non-manual classes was 1.7 (95% Cl : 1.47-1.98). (...) |
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