| Titre : | The next stage : Molecular epidemiology. Commentary. (1997) |
| Auteurs : | O. SHPILBERG ; J.S. DORMAN ; R.E. FERRELL ; L.H. KULLER ; A. SHAHAR ; M. TRUCCO ; Department of Epidemiology. Graduate School of Public Health. University of Pittsburgh. Pittsburgh Pennsylvania. USA |
| Type de document : | Article |
| Dans : | Journal of clinical epidemiology (vol. 50, n° 6, 1997) |
| Pagination : | 633-638 |
| Langues: | Anglais |
| Mots-clés : | Hérédité ; Homme ; Carcinogène ; Médicament ; Immunologie ; Alimentation ; Facteur risque ; Prévention santé ; Génétique ; Epidémiologie |
| Résumé : | [BDSP. Notice produite par INIST G9DpR0xA. Diffusion soumise à autorisation]. The traditional approach in epidemiology of relating exposure to an environmental agent such as a drug or infective agent has been to measure an overall risk (i.e., average and then "adjust risk for demographic variables and other confounders"). An attempt is sometimes made to define a "susceptible" subgroup. The analyses are usually based on good statistical methodology rather than an understanding of the interaction of body of host and agent. A twofold risk for 1000 exposed versus nonexposed people could be an average twofold risk for all 1000 exposed or a 20-fold risk for 100 exposed individuals (i.e., a drug-host interaction). Clearly, finding the 100 individuals with a 20-fold risk has much greater clinical importance than a twofold risk for 1000 people. The world of epidemiology may be changing-we may soon he able to define risk based on genetic susceptibility, at least sometimes. |
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