| Titre : | Prevalence of melanocytic nevi and freckles in young Israeli males correlation with melanoma incidence in jewish migrants : Demographic and host factors. (1997) |
| Auteurs : | F. PAVLOTSKY ; E. AZIZI ; V. BARELL ; R. GURVICH ; J. ISCOVICH ; A. LUSKY ; M. WEINER ; Department of Dermatology. Chaim Sheba Medical Center. Sackler Faculty of Medicine. Tel Aviv University. Tel Hashomer. ISR ; Health Services Research Unit. Chaim Sheba Medical Center. Israel Ministry of Health. Tel Hashomer. ISR |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 146, n° 1, 1997) |
| Pagination : | 78-86 |
| Langues: | Anglais |
| Mots-clés : | Adolescent ; Homme ; Israël ; Asie ; Epidémiologie ; Mélanome ; Migrant ; Hérédité ; Lieu naissance ; Soleil ; Facteur risque ; Peau [pathologie] ; Tumeur |
| Résumé : | [BDSP. Notice produite par INIST R0x37L0r. Diffusion soumise à autorisation]. The role of host and environmental factors in the pathogenesis of multiple melanocytic nevi, atypical nevi, and freckles was studied in 1989 in a random sample of 3,040 Israeli males aged 17 years. Multiple melanocytic nevi were significantly associated with family history of melanoma or multiple melanocytic nevi (odds ratio (OR)=15.0), fair or lightly pigmented skin color (OR=2.7 and 2.3, respectively), and affiliation to the high or heterogenous melanoma risk group, determined by the incidence rates of melanoma in Jewish migrants from corresponding origin (OR=3.1 and 2.1, respectively). An environment-related effect may account for the increased multiple melanocytic nevi risk among second- (OR=8.2) compared with first-generation, native-born recruits (OR=3.0) from the high melanoma risk group whose families had been living in Israel the longest. Atypical nevi were associated with fair (OR=6.1) and lightly pigmented (OR=3.5) skin color, high and moderate sunburn susceptibility (OR=4.7 and 2.5, respectively), and family history of melanoma or multiple melanocytic nevi (OR=4.7). Freckles were significantly associated with sun-sensitive phenotype, family history of melanoma or multiple melanocytic nevi (OR=1.5), Conservative (OR=1.9) or nonreligious status (OR=1.9), and high (OR=2.4) or heterogenous melanoma risk groups (OR=1.8). (...) |
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