| Titre : | Relation between birth weight and the insulin sensitivity index in a population sample of 331 young, healthy caucasians. (1997) |
| Auteurs : | J.O. CLAUSEN ; K. BORCH-JOHNSEN ; O. PEDERSEN ; Copenhagen County. Center of Preventive Medicine. Medical Department C. Glostrup University Hospital. Gentofte. DNK ; Steno Diabetes Center. Gentofte. DNK |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 146, n° 1, 1997) |
| Pagination : | 23-31 |
| Langues: | Anglais |
| Mots-clés : | Poids naissance ; Epidémiologie ; Insuline ; Sensibilité ; Danemark ; Europe ; Anthropométrie ; Sexe ; Glucose ; Jeune adulte ; Homme |
| Résumé : | [BDSP. Notice produite par INIST 61N4MR0x. Diffusion soumise à autorisation]. The objective was to study the association between birth weight and the insulin sensitivity index. Altogether, 331 unrelated Caucasian subjects aged 18-32 years with measures of the insulin sensitivity index and insulin secretion during a combined intravenous glucose and tolbutamide tolerance test were included in the study. The data on birth weight and length were obtained from the midwife records. The study took place in Copenhagen, Denmark, during 1992-1993. Univariately, a significant positive association between birth weight and the insulin sensitivity index was found in women (p=0.045), but not in men (p=0.23). In multivariate analysis, controlling for age, gender, body mass index, waist circumference, maximal aerobic capacity, and use of oral contraceptives, no significant interaction between birth weight and gender that considered the insulin sensitivity index was found. The insulin sensitivity index was significantly associated with birth weight (p=0.0012), corresponding to an increase of 1.7% (95% confidence interval 0.7-2.7%) in the insulin sensitivity index for each 100-g increase in birth weight. In comparison, an increase in body mass index of 1 kg/m2 (a weight gain of 2.9 kg in a man 1.70 m tall) corresponds to a decrease in the insulin sensitivity index of 3.8% (95% confidence interval 0.7-6.8%), an increase in waist circumference of 1 cm corresponds to a decrease in the insulin sensitivity index of 2.1% (95% confidence interval 0.9-3.1 %) (...) |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact