| Titre : | Risk factors for renal cell cancer : The multiethnic cohort. (2007) |
| Auteurs : | Veronica WENDY SETIAWAN ; Brian-E HENDERSON ; Laurence-N KOLONEL ; Abraham-My NOMURA ; Daniel-O STRAM |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 166, n° 8, 2007) |
| Pagination : | 932-940 |
| Langues: | Anglais |
| Mots-clés : | Hypertension artérielle ; Tabagisme ; Facteur risque ; Ethnie ; Taille corporelle ; Rein ; Diurétique ; Tabac ; Epidémiologie ; Homme ; Cancer ; Appareil urinaire ; Anthropométrie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS n8yR0xFu. Diffusion soumise à autorisation]. The association of body size, lifestyle, and medical conditions with renal cell cancer risk was examined among 161,126 Hawaii-Los Angeles Multiethnic Cohort participants (1993-2002). After 8.3 years of follow-up, 347 renal cell cancer cases (220 men, 127 women) were identified. Renal cell cancer risk increased with increasing body mass index in men (multivariate relative risk (RR)=1.06 per unit of body mass index, p=0.001) and women (RR=1.07, p<0.0001). The relative risks associated with being obese compared with being lean were 1.76 (95% confidence interval (Cl) : 1.20,2.58) for men and 2.27 (95% Cl : 1.37,3.74) for women. Hypertension was associated with renal cell cancer (RRmen=1.42,95% Cl : 1.07,1.87 ; RRwomen=1.58,95% Cl : 1.09,2.28). Smoking was confirmed to be a risk factor for both sexes. Among women, diuretic use was associated with increased risk (RR=1.63,95% Cl : 1.04,2.57), whereas physical activity was associated with reduced risk (ptrend=0.027). Alcohol consumption was inversely associated with risk for men (ptrend=0.045). Compared with nondrinkers, men who drank>1 drinks/day had a 31% lower risk (95% Cl : 0.49,0.96). Results show that body mass index, smoking, and hypertension are risk factors for renal cell cancer in both sexes. |
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