| Titre : | Retinopathy and survival in a population without diabetes : The beaver dam eye study. (2007) |
| Auteurs : | HIRAI (Flavio-E) : BRA. Department of Ophthalmology. Federal University of Sao Paulo. Sao Paulo. ; Barbara-Ek Klein ; Ronald Klein ; Michael-D KNUDTSON ; Scot-E MOSS |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 166, n° 6, 2007) |
| Pagination : | 724-730 |
| Langues: | Anglais |
| Mots-clés : | Rétinopathie ; Diabète ; Survie ; Population ; Homme ; Oeil ; Mortalité ; Epidémiologie ; Ophtalmologie ; Rétine ; Glande endocrine [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS BxjoR0xi. Diffusion soumise à autorisation]. Retinopathy is relatively common in nondiabetic populations, and its long-term prognostic implications are not certain. For this reason, the authors hypothesized that retinal alterations were associated with all-cause and cause-specific mortality in nondiabetic individuals participating in the Beaver Dam Eye Study in Wisconsin. Included in the analysis were 4,294 nondiabetic subjects aged 43-84 years examined at baseline (1988-1990). Retinopathy was classified into four groups by using retinal photographs : 1) no retinopathy, 2) presence of retinal hemorrhages only, 3) presence of retinal microaneurysms only, and 4) presence of moderate or worse retinopathy. The authors analyzed survival during 14 years of follow-up and in 5-year intervals by using time-varying covariates. Baseline prevalence of retinopathy was 7.7%. Adjusting for age, sex, and significant confounders, they observed that moderate retinopathy at baseline was associated with all-cause (hazard ratio=1.76,95% confidence interval : 1.16,2.69) and ischemic heart disease (hazard ratio=3.17,95% confidence interval : 1.73,5.78) mortality after 14 years of follow-up. In the 5-year-interval analysis, the presence of hemorrhages only was significantly related to increased all-cause (hazard ratio=1.49,95% confidence interval : 1.05,2.12) and ischemic heart disease (hazard ratio=2.43,95% confidence interval : 1.48,4.01) mortality. Study results suggest that retinal changes have possible prognostic implications regarding survival of persons without diabetes. |
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