| Titre : | Serum insulin-like growth factor I and subsequent risk of colorectal cancer among Japanese-American men. (2003) |
| Auteurs : | Abraham-My NOMURA ; James LEE ; Michael-N POLLAK ; Grant-N STEMMERMANN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 158, n° 5, 2003) |
| Pagination : | 424-431 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Rectum ; Sérum ; Facteur risque ; Epidémiologie ; Homme ; Appareil digestif [pathologie] ; Intestin [pathologie] ; Côlon |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0x9Wp5I. Diffusion soumise à autorisation]. Recent reports suggest that colorectal cancer is positively related to insulin-like growth factor I (IGF-I) and inversely related to insulin-like growth factor binding protein 3 (IGFBP-3). To evaluate these associations further and separately for colon and rectal cancer, the authors conducted a nested case-control study in a cohort of 9,345 Japanese-American men examined in Hawaii in 1971-1977. A total of 177 incident colon cancer cases and 105 incident rectal cancer cases were identified from 1972 to 1996. These patients'stored sera and those of 282 age-matched controls were measured for IGF-I and IGFBP-3. The adjusted mean level of IGF-I was higher in colon cancer cases than in controls (154.7 ng/ml vs. 144.4 ng/ml ; p=0.01). However, the multivariate odds ratio for the highest quartile compared with the lowest was just 1.8 (95% confidence interval : 0.8,4.3). Adjusted mean IGF-I levels were similar between rectal cancer cases and their controls. For IGFBP-3, adjusted mean levels were lower for both colon and rectal cancer cases than for their matched controls, but the differences were not significant. The IGF-I results weakly support findings from other studies and suggest that there are differences in IGF-I findings between colon and rectal cancer cases. It is possible that IGF-related risk is confounded by other factors that may vary among different cohorts. Further research is needed to clarify these relations. |
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