Prospects of genetic epidemiology in the 21st cent... Catalogue en ligne

Titre :	Prospects of genetic epidemiology in the 21st century. (2003)
Auteurs :	Marieke-Cj DEKKER ; Cornelia-M VAN DUIJN ; Department of Epidemiology and Biostatistics. Erasmus Mc. Rotterdam. NLD
Type de document :	Article
Dans :	European journal of epidemiology (vol. 18, n° 7, 2003)
Pagination :	607-616
Langues:	Anglais
Mots-clés :	21 siècle ; Homme ; Hérédité ; Pathologie ; Méthodologie
Résumé :	[BDSP. Notice produite par INIST-CNRS CR0x4129. Diffusion soumise à autorisation]. Genetic epidemiology is a young but rapidly developing discipline. Although its early years were largely dedicated to family-based research in monogenic disorders, now genetic-epidemiologic research increasingly focuses on complex, multi factorial disorders. Along with the development of the human-genome map and advances in molecular technology grows the importance of genetic-epidemiologic applications. Large-scale population-based studies, requiring close integration of genetic and epidemiologic research, determine future research in the field. In this paper, we review the basic principles underlying genetic-epidemiologic research, such as molecular genetics and familial aggregation of disease, as well as the typical study approaches of genome screening and candidate-gene studies.

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