Résumé :
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[BDSP. Notice produite par INIST 68sMR0x6. Diffusion soumise à autorisation]. Patterns of measles transmission at school and at home were studied in 1995 in a rural area of Senegal with a high level of vaccination coverage. Among 209 case children with a median age of 8 years, there were no deaths, although the case fatality ratio has previously been 6-7% in this area. Forty percent of the case children had been vaccinated against measles ; the proportion of vaccinated children was higher among secondary cases (47%) than among index cases (33%) (prevalence ratio=1.36,95% confidence interval (Cl) 1.04-1.76). Vaccinated index cases may have been less infectious than unvaccinated index cases, since they produced fewer clinical cases among exposed children (relative risk=0.55,95% Cl 0.29-1.04). The secondary attack rate was lower in the schools than in the homes (relative risk=0.31,95% Cl 0.20-0.49). The school outbreaks were protracted, with 4-5 generations of cases being seen in the two larger schools. Vaccine efficacy was found to be 57% (95% Cl - 23 to 85) in the schools and 74% (95% Cl 62-82) in the residential compounds. Measles infection resulted in a mean of 3.8 days of absenteeism per case, though this did not appear to have an impact on the children's grades. Among the index cases, 56% of children were probably infected by neighbors in the community, and 7% were probably infected at health centers, 13% outside the community, and 24% in one of the three schools which had outbreaks during the epidemic. (...)
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