Résumé :
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[BDSP. Notice produite par INIST-CNRS tQR0xhZU. Diffusion soumise à autorisation]. Context : Exposure to cardiovascular risk factors during childhood and adolescence may be associated with the development of atherosclerosis later in life. Objective : To study the relationship between cardiovascular risk factors measured in childhood and adolescence and common carotid artery intima-media thickness (IMT), a marker of preclinical atherosclerosis, measured in adulthood. Design, Setting, and Participants : Population-based, prospective cohort study conducted at 5 centers in Finland among 2229 white adults aged 24 to 39 years who were examined in childhood and adolescence at ages 3 to 18 years in 1980 and reexamined 21 years later, between September 2001 and January 2002. Main Outcome Measures : Association between cardiovascular risk variables (levels of low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and triglycerides ; LDL-C/HDL-C ratio ; systolic and diastolic blood pressure ; body mass index ; smoking) measured in childhood and adulthood and common carotid artery IMT measured in adulthood. Results In multivariable models adjusted for age and sex, IMT in adulthood was significantly associated with childhood LDL-C levels (P=001), systolic blood pressure (P<. body mass index and smoking with adult systolic blood pressure the number of risk factors measured in adolescents including high levels extreme age-and sex-specific percentile ldl-c cigarette were directly related to carotid imt young adults at ages through years for both men women remained significant after adjustment contemporaneous variables. demonstrated a weak direct relationship but not conclusions : factor profile assessed predicts common artery independently factors. these findings suggest that exposure cardiovascular early life may induce changes arteries contribute development atherosclerosis.>
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