| Titre : | Community-based study of hepatitis C virus infection and type 2 diabetes : An association affected by age and hepatitis severity status. (2003) |
| Auteurs : | Chong-Shan WANG ; Ting-Tsung CHANG ; Pesus CHOU ; Shan-Tair WANG ; Wei-Jen YAO ; National Cheng Kung University. College of Medicine. Institute of Public Health. Tainan. TWN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 158, n° 12, 2003) |
| Pagination : | 1154-1160 |
| Langues: | Anglais |
| Mots-clés : | Hépatite virale C ; Virose ; Infection ; VHC ; Virus ; Homme ; Age ; Physiopathologie ; Etiologie ; Glande endocrine [pathologie] ; Appareil digestif [pathologie] ; Foie [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xE5iPd. Diffusion soumise à autorisation]. Past studies of the relation between hepatitis C virus (HCV) infection and type 2 diabetes conflict. The authors aimed to elucidate the relation by using a large community-based sample with a wide range of liver conditions. Between October 1997 and February 1998,2,327 consecutive subjects (aged>=35 years) were enrolled at the public health facility in Taiwan. Blood sugar, hepatitis B surface antigen, and antibody for HCV (anti-HCV) were tested. Abdominal sonography was performed on viral-hepatitis-positive subjects. In univariate analysis, older age, lower educational levels, sedentary work, body mass index of>=25 kg/m2, and anti-HCV positivity were significantly associated with type 2 diabetes (p<0.05), but smoking, alcohol consumption, gender, and hepatitis B surface antigen status were not. In multivariate logistic regression, anti-HCV positivity was strongly associated with type 2 diabetes in subjects aged 35-49 years (odds ratio (OR)=3.3,95% confidence interval (Cl) : 1.4,8.0) and 50-64-years (OR=1.6,95% Cl : 1.1,2.5). Sonographic evidence of fatty liver (OR=2.4,95% Cl : 1.2,4.8) and chronic liver disease (OR=2.0,95% Cl : 1.0,4.2) in anti-HCV-positive subjects was moderately associated with type 2 diabetes after age and gender adjustment. Data suggest that HCV infection is moderately associated with type 2 diabetes ; the association was strongest for subjects aged 35-49 years and increased with severity of the liver condition. |
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