| Titre : | Childhood cardiovascular risk factors and Carotid vascular changes in adulthood : The Bogalusa heart study. (2003) |
| Auteurs : | . SHENGXU LI ; Gerald-S BERENSON ; Mgene BOND ; . RUNG TANG ; Sathanur-R SRINIVASAN ; Elaine-M URBINA ; . WEI CHEN ; Tulane University Health Sciences Center. Department of Epidemiology. New Orleans. LA. USA ; Tulane University Health Sciences Center. Tulane Center for Cardiovascular Health. New Orleans. LA. USA ; Wake Forest University School of Medicine. Division of Vascular Ultrasound Research. Winston Salem. NC. USA |
| Type de document : | Article |
| Dans : | JAMA - Journal of the american medical association (vol. 290, n° 17, 2003) |
| Pagination : | 2271-2276 |
| Langues: | Anglais |
| Mots-clés : | Appareil circulatoire [pathologie] ; Homme ; Enfant ; Facteur risque ; Adulte ; Pression artérielle ; Lipoprotéine ; Média |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 8Ww1R0xD. Diffusion soumise à autorisation]. Context : Carotid artery intima-media thickness (IMT) is associated with cardiovascular risk factors and is recognized as an important predictive measure of clinical coronary atherosclerosis events in middle-aged and elderly populations. However, information on the association of carotid IMT in young adults with different risk factors measured in childhood, adulthood, or as a cumulative burden of each of the risk factors measured serially from childhood to adulthood is limited. Objective : To examine the association between carotid IMT in young adults and traditional cardiovascular risk factors measured since childhood. Design, Setting, and Participants : A cohort study of 486 adults aged 25 to 37 years from a semirural black and white community in Bogalusa, La (71% white, 39% men), who had at least 3 measurements of traditional risk factors since childhood, conducted between September 1973 and December 1996. Main Outcome Measure : Association of carotid IMT with risk factors, including systolic blood pressure, lipoprotein levels, and body mass index. Results : Male vs female (0.757 mm vs 0.719 mm) and black vs white (0.760 mm vs 0.723 mm) participants had increased carotid IMT (P<. 001 for both). In multivariable analyses, significant predictors for being in top vs lower 3 quartiles of carotid IMT in young adults were childhood measures of low-density lipoprotein cholesterol (LDL-C) level (odds ratio [OR], 1.42, corresponding to 1 - SD change specific for age, race, and sex ; 95% confidence interval [cl], 1.14-1.78) and body mass index (BMI ; OR, 1.25 ; 95% cl, 1.01-1.54) ; adulthood measures of LDL-C level (OR, 1.46 ; 95% cl, 1.16-1.82), - high-density lipoprotein cholesterol (HDL-C) level (OR, 0.67 ; 95% cl, 0.51-0.88), and systolic blood pressure (OR, 1.36 ; 95% cl, 1.08-1.72) ; and long-term cumulative burden of LDL-C (OR, 1.58 ; 95% cl, 1.24-2.01) and HDL-C (OR, 0.75 ; 95% Cl, 0.58-0.97) levels measured serially from childhood to adulthood. An increasing trend in carotid IMT across quartiles of LDL-C level measured in childhood was observed, with a mean value of 0.761 mm (95% cl, 0.743-0.780 mm) for those at the top quartile vs 0.724 mm (95% Cl, 0.715-0.734 mm) for those in the lower 3 quartiles (P<. 001). Conclusions : Childhood measures of LDL-C level and BMI predict carotid IMT in young adults. The prevention implications of these findings remains to be explored. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact