| Titre : | Crohn's disease, ulcerative colitis, and measles vaccine in an English population, 1979-1998. (2003) |
| Auteurs : | V. SEAGROATT ; M.J. GOLDACRE ; University of Oxford. Department of Public Health. Unit of Health Care Epidemiology. Oxford. GBR |
| Type de document : | Article |
| Dans : | Journal of epidemiology and community health (vol. 57, n° 11, 2003) |
| Pagination : | 883-887 |
| Langues: | Anglais |
| Mots-clés : | Maladie Crohn ; Vaccin ; Homme ; Rectocolite hémorragique ; Virus ; Rougeole ; Virose ; Infection ; Vaccination ; Prévention santé ; Appareil digestif [pathologie] ; Intestin [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS AbR0xRm7. Diffusion soumise à autorisation]. Study objectives : To study the hospitalised incidence of Crohn's disease (CD) and ulcerative colitis (UC) from 1979 to 1998 ; and to determine whether the introduction of the measles vaccination programme was associated with an increase in the young. Design : Analysis of linked data on hospital admissions ; a cohort analysis of the effect of the measles vaccination programme on the incidence of hospitalised CD and UC ; and a comparison of these results with those from previous studies on the association between measles vaccine and CD or UC. Settings : Southern England. Subjects : People admitted to hospital with a main diagnosis of CD (1959 people) or UC (2018 people). Main results : Overall, the incidence of hospitalised CD showed no significant change over the 20 year period : the average change per year was 0.08% (95% confidence interval : - 0.7% to 0.9%). The relative risk associated with the measles vaccination programme was not significant (0.91 : 0.5 to 1.4). The estimate differed significantly from the relative risk of 3.0 obtained in the original study reporting an association, but agreed with the combined estimate from three subsequent studies (0.95 : 0.6 to 1.5). The results for UC were similar. Conclusions : The incidence of hospitalised CD and UC remained stable over the 20 years, 1979 to 1998. Whatever caused the marked increases in CD and UC in the mid-20th century must itself have stabilised in this region. These results, together with those from other studies, provide strong evidence against measles vaccine causing CD or UC. |
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