| Titre : | Body iron stores in relation to risk of Type 2 diabetes in apparently healthy women. (2004) |
| Auteurs : | . RUI JIANG ; Frank-B HU ; . JING MA ; Joann-E MANSON ; James-B MEIGS ; Nader RIFAI ; Channing Laboratory. Boston. USA ; Harvard Medical School. Department of Medicine. Boston. USA ; Harvard School of Public Health. Department of Epidemiology. Boston. USA ; Harvard School of Public Health. Department of Nutrition. Boston. USA |
| Type de document : | Article |
| Dans : | JAMA - Journal of the american medical association (vol. 291, n° 6, 2004) |
| Pagination : | 711-717 |
| Langues: | Anglais |
| Mots-clés : | Fer ; Facteur risque ; Risque ; Femme ; Homme ; Incidence ; Epidémiologie ; Glande endocrine [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 8OHAR0xb. Diffusion soumise à autorisation]. Context : Type 2 diabetes is a common manifestation of hemochromatosis, a disease of iron overload. However, it is not clear whether higher iron stores predict the development of type 2 diabetes in a healthy population. Objective : To examine plasma ferritin concentration and the ratio of the concentrations of transferrin receptors to ferritin in relation to risk of type 2 diabetes. Design, Setting, and Participants : 1989-1990 and were free of diagnosed diabetes, cardiovascular disease, and cancer, 698 developed diabetes during 10 years of follow-up. The controls (n=716) were matched to cases on age, race, and fasting status ; and on body mass index (BMI) for cases in the top BMI decile. Main Outcome Measure Incident cases of type 2 diabetes. Results : Among cases, the mean (SD) concentration of ferritin was significantly higher (109 [105] vs 71.5 [68.7] ng/mL for controls ; P<. 001 for difference) and the mean (SD) ratio of transferrin receptors to ferritin was significantly lower (102 [205] vs 141 [340], respectively ; P=01). In conditional logistic regression stratified on the matching factors and controlled for BMI and other diabetes risk factors, the multivariate relative risks [RRs] of incident type 2 diabetes across increasing quintiles of ferritin were 1.00,1.09 (95% confidence interval [Cl], 0.70-1.70), 1.26 (95%% Cl, 0.82-1.95), 1.30 (95% Cl, 0.83-2.04), and 2.68 (95% Cl, 1.75-4.11) (P<. 001 for trend). The RRs across increasing quintiles of transferrin receptors to ferritin ratio were 2.44 (95% Cl, 1.61-3.71), 1.00 (95% Cl, 0.64-1.56), 1.13 (95% Cl, 0.73-1.74), 0.99 (95% Cl, 0.64-1.53), and 1.00 (P=01 for trend). Further adjustment for an inflammatory marker (C-reactive protein) did not change the results appreciably. The associations persisted within strata defined by levels of BMI, menopausal status, alcohol consumption, and C-reactive protein. Conclusion : Higher iron stores (reflected by an elevated ferritin concentration and a lower ratio of transferrin receptors to ferritin) are associated with an increased risk of type 2 diabetes in healthy women independent of known diabetes risk factors. |
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