| Titre : | Influence of maternal human immunodeficiency virus (HIV) co-infection on vertical transmission of hepatitis C virus (HCV) : a meta-analysis : Infectious diseases. (2003) |
| Auteurs : | PAPPALARDO (Brandee-L) : USA. Blood Centers of the Pacific. Irwin Center. San Francisco CA. |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 32, n° 5, 2003) |
| Pagination : | 727-734 |
| Langues: | Anglais |
| Mots-clés : | Hépatite virale C ; Virose ; Infection ; Mère ; Hépatite virale A ; Sida ; VIH ; Rétrovirus ; Virus ; VHC ; Homme ; Nouveau né ; Femme ; Epidémiologie ; Immunopathologie ; Appareil digestif [pathologie] ; Foie [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS uR0xGyr5. Diffusion soumise à autorisation]. Background : Maternal co-infection with human immunodeficiency virus (HIV) has been implicated as a potentially important co-factor for enhanced vertical transmission of hepatitis C virus (HCV). In previous reports, however, methodological issues (notably small sample sizes) have limited accurate evaluation of the contribution of maternal co-infection with HIV on the risk of vertical transmission of HCV. Methods : A systematic review and subsequent meta-analysis of current published and unpublished reports was performed. Odds ratios (OR) and 95% CI for individual studies were calculated with maternal HIV serostatus as the exposure measure and HCV vertical transmission as the outcome measure. Overall summary estimates were then calculated using a random effects model that estimates a weighted average of OR from individual studies. Results : In total, 2382 infants from 10 studies were included in an analysis of HCV-infected mothers (defined by anti-HCV+antibody assays) with and without concomitant HIV infection. The risk estimate (OR) of HCV vertical transmission was 2.82 (95% CI : 1.78-4.45 ; P=0.00001) from anti-HCV+/HIV+co-infected mothers compared with anti-HCV+/HIV-mothers. In a subanalysis of 1327 infants born to viraemic (HCV RNA+) mothers, the risk estimate of HCV vertical transmission was 1.97 (95% CI : 1.04-3.74 ; P=0.04) from HCV viraemic/HIV+co-infected mothers compared with HCV viraemic/HIV-mothers. Conclusions : Results from this meta-analysis of observational studies suggest that the risk of HCV vertical transmission is higher in infants born to HIV co-infected mothers. |
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