Résumé :
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[BDSP. Notice produite par INIST-CNRS TiyR0xG5. Diffusion soumise à autorisation]. Multidrug-resistant tuberculosis (MDR-TB) presents an Increasing threat to global tuberculosis control. Many crucial management Issues in MDR-TB treatment remain unanswered. We reviewed the existing scientific research on MDR-TB treatment, which consists entirely of retrospective cohort studies. Although direct comparisons of these studies are impossible, some insights can be gained : MDR-TB can and should be addressed therapeutically In resource-poor settings ; starting of treatment early Is crucial ; aggressive treatment regimens and high-end dosing are recommended given the lower potency of second-line antituberculosis drugs ; and strategies to Improve treatment adherence, such as directly observed therapy, should be used. Opportunities to treat MDR-TB In developing countries are now possible through the Global Fund to Fight AIDS, TB, and Malaria, and the Green Light Committee for Access to Second-line Antituberculosis Drugs. As treatment of MDR-TB becomes increasingly available in resource-poor areas, where it is needed most, further clinical and operational research is urgently needed to guide clinicians in the management of this disease.
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