| Titre : | Meta-analysis of the association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease : A HuGE gene-disease association review. (2004) |
| Auteurs : | Christos NTAIS ; IOANNIDIS (John-Pa) : GRC. Biomedical Research Institute. Foundation for Research and Technology-Hellas. Ioannina. ; Anastasia POLYCARPOU ; University of loannina School of Medicine. Department of Hygiene and Epidemiology. Clinical and Molecular Epidemiology Unit. Ioannina. GRC |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 159, n° 6, 2004) |
| Pagination : | 527-536 |
| Langues: | Anglais |
| Mots-clés : | Démence Alzheimer ; Risque cumulé ; Facteur associé ; Association ; Enzyme ; Gène ; Génétique ; Facteur risque ; Risque ; Epidémiologie ; Homme ; Maladie dégénérative ; Système nerveux [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 95iR0xKt. Diffusion soumise à autorisation]. A C-to-T polymorphism in exon 2 of the cathepsin D gene encoding cathepsin D (CTSD) has been implicated as a risk factor for Alzheimer's disease. The authors performed a meta-analysis of 14 studies (16 comparisons) with CTSD genotyping (3,174 Alzheimer's disease cases and 3,298 controls). Overall, the random effects odds ratio for the T versus the C allele was 1.17 (95% confidence interval (Cl) : 0.95,1.44), with some between-study heterogeneity (p<0.01). There was significant between-study heterogeneity but no evidence of a significant association when the first hypothesis-generating study was excluded from the calculations (odds ratio (OR)=1.11,95% Cl : 0.91,1.35 ; p=0.29). The summary odds ratio for T carriers versus T non carriers was similar in subjects carrying or not carrying an apolipoprotein E epsilon4 allele (APOE*4). The increased susceptibility to Alzheimer's disease conferred by APOE*4 carriage tended to be more prominent in the presence of the T allele (random effects OR=6.07,95% Cl : 4.19,8.79, and OR=4.09,95% Cl : 3.15,5.31, in Tcarriers and non carriers, respectively). The meta-analysis shows that the CTSD polymorphism is not a major risk factor for Alzheimer's disease, although a small effect or an enhancement of the APOE*4 effect cannot be excluded. |
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