| Titre : | Does the addition of information on genotype improve prediction of the risk of melanoma and nonmelanoma skin cancer beyond that obtained from skin phenotype ? (2004) |
| Auteurs : | Terence DWYER ; Rosie ASHBOLT ; Marianne BERWICK ; Leigh BLIZZARD ; Joanne-L DICKINSON ; Liesel-M FITZGERALD ; Anne REILLY ; Michèle-M SALE ; James-M STANKOVICH ; Jan WILLIAMSON ; University of Tasmania. Menzies Research Institute. Hobart Tasmania. AUS |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 159, n° 9, 2004) |
| Pagination : | 826-833 |
| Langues: | Anglais |
| Mots-clés : | Information ; Cancer ; Facteur risque ; Risque ; Peau ; Homme ; Information épidémiologique ; Epidémiologie ; Génétique |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xCB2PW. Diffusion soumise à autorisation]. The authors quantified improvement in predicting cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma of the skin made possible by information on common variants of the melanocortin-1 receptor gene (MC1R) in a 1998-1999 population-based case-control study of subjects aged 20-59 years of northern European ancestry in Tasmania, Australia. Melanin density at the upper inner arm was estimated by spectrophotometry. DNA samples were genotyped for five MC1R variants : Val60Leu, Asp84Glu, Arg151Cys, Arg160Trp, and Asp294His. Among controls (n=267), variant carriers, versus noncarriers, had lower (p<0.01) mean melanin concentrations. Increased risk conferred by genotype was restricted mainly to those with the darkest skins : for subjects with at least 2% melanin, the odds of carrying each additional variant were higher for cutaneous malignant melanoma (n=39 ; odds ratio=1.45,95% confidence interval : 0.87,2.44), basal cell carcinoma (n=35 ; odds ratio=1.86,95% confidence interval : 1.14,3.02), and squamous cell carcinoma (n=42 ; odds ratio=2.67,95% confidence interval : 1.50,4.74) cases than for controls (n=135). Adding MC1R information to prediction based on age, sex, and cutaneous melanin increased the area under the receiver operating characteristic curve by 1.4% (cutaneous malignant melanoma), 3.2% (basal cell carcinoma), or 2.0% (squamous cell carcinoma). The improvement in prediction was probably too small to be valuable in a clinical setting. |
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